Avanafil: Price, Dosage & Where to Buy

Avanafil is a second-generation, highly selective PDE5 inhibitor. It is most commonly prescribed for erectile dysfunction in adult males, helping support an erection when there is sexual stimulation. Avanafil requires a prescription in the United Kingdom and is available as a generic medicine since 2024-06-14.

Avanafil is indicated for the treatment of erectile dysfunction in adult males. Erectile dysfunction means difficulty getting or keeping an erection suitable for sexual activity. Avanafil does not create sexual desire and sexual stimulation is needed for a response.

Assessment of erectile dysfunction should consider possible underlying causes and suitable treatment options. The medicine is not indicated for females or paediatric patients. Safety and effectiveness have not been established in patients below the age of 18 years.

Avanafil belongs to a group of medicines called PDE5 inhibitors. During sexual stimulation, natural signals in the penis increase a chemical messenger called cyclic guanosine monophosphate. This relaxes smooth muscle and widens blood vessels, allowing more blood to enter the erectile tissue.

PDE5 normally breaks down this messenger. By blocking PDE5, avanafil helps maintain the chemical signal for longer and can support an erection.

Sexual stimulation is still required, so the medicine does not cause an erection on its own. Avanafil also has blood-vessel-widening effects elsewhere in the body, which can lower blood pressure and explains some important interactions.

The label lists 50 mg, 100 mg, and 200 mg oral tablets. The usual starting dose is 100 mg as needed, as early as approximately 15 minutes before sexual activity. The label lists a possible increase to 200 mg as early as approximately 15 minutes before sexual activity, or a reduction to 50 mg approximately 30 minutes before sexual activity, based on efficacy and tolerability.

The label lists use no more than once a day. The label lists use with or without food. The label lists 50 mg as the starting dose for patients on stable alpha-blocker therapy.

The label lists a maximum of 50 mg in a 24-hour period for patients using a moderate CYP3A4 inhibitor. The lowest dose that provides benefit should be used, and sexual stimulation is required for a response.

Avanafil is used as needed rather than on a fixed daily schedule. A missed dose usually means the planned use was not taken before sexual activity.

Do not double the amount to make up for a missed dose. A pharmacist or prescriber can advise about the next planned use, especially when other medicines or health conditions are involved.

Avanafil is not indicated for use in females. There are no data from pregnant women to inform risks for adverse developmental outcomes, and there is no information about its presence in human or animal milk, effects on a breastfed child, or effects on milk production.

Discuss pregnancy or breastfeeding questions with a doctor or pharmacist. The label also states that no studies have evaluated the effect of avanafil on fertility in men.

Store at controlled room temperature 25°C, with excursions permitted to 15° to 30°C. Protect the tablets from light. Keep them in the original packaging and away from moisture, children, and anyone for whom they were not prescribed, as directed on the label.